Antisense is a limited sequence of DNA in the antisense direction 3′–5′ designed from knowing the sequence of a target gene. Is the coding strand the sense strand? The other strand is called the coding strand, because its sequence is the same as the RNA sequence that is produced, with the exception of U replacing T. Antisense RNA binds the primer inhibiting the processing of RNA primer and replication of the plasmid, hence the plasmid copy number may be regulated (Tomizawa et al. 1981). Likewise, Staphylococcus aureus plasmid (pT 181) replication and copy number appear to be controlled by antisense RNA (Kumar and Novick, 1985). 1 Answer. Sorted by: 3. Both mRNA and pre-mRNA would be considered "sense". The term "sense" means that the strand is the direct coding strand. That is, the strand that has the proper codons to be translated into the protein of interest. This term can be applied to both DNA and RNA. The term "anti-sense" means that the strand is Watson-Crick Antisense oligonucleotides (ASOs) are small sequences of DNA able to target RNA transcripts resulting in reduced or modified protein expression. ASOs are ideal candidates for the treatment of neurodegenerative diseases given numerous advancements made to their chemical modifications and delivery methods. Antisense oligonucleotide (ASO) drugs are a type of chemically modified DNA that can be injected into cerebrospinal fluid in order to enter brain cells and reduce the amount of RNA from a specific gene. The brain is a complex mixture of hundreds of billions of cells. If a DNA sequence directly gives the same mRNA sequence from the transcription, it is known as positive sense or sense DNA. If a DNA sequence produces complementary mRNA sequence from the transcription, it is known as negative sense or antisense DNA. Okwrgcj.

dna sense vs antisense